Transdermal administration of drugs is generally limited by the barrier function of the skin.Vesicular systems are one of the most controversial methods for transdermal delivery of active substances.The interest in designing transdermal delivery systems was relaunched after the discovery of elastic vesicles like transferosomes, ethosomes, cubosomes
A group sequential design allows investigators to sequentially monitor efficacy and safety as part of interim testing in phase III trials.Literature is well developed in the case of continuous and binary outcomes, however, Placemats in case of trials with a time-to-event outcome, popular methods of sample size calculation often assume proportional
With the rapid development of AI techniques, Computer-aided Diagnosis has attracted much attention and has been successfully deployed in many applications of Trees health care and medical diagnosis.For some specific tasks, the learning-based system can compare with or even outperform human experts’ performance.The impressive performance owes
BackgroundContinuous interscalene block has been known to improve postoperative analgesia after arthroscopic shoulder surgery.This was a prospective study investigating the ultrasound-guided posterior approach for placement of an interscalene catheter, clinical efficacy and complications after placement of the catheter.MethodsForty-two patients und
Sour rot (SR) is a grapevine disease complex that is not completely understood in its etiology and epidemiology.Recently, SR has received special attention due to its increasing economic importance due to crop losses and reduced wine quality.In this study, the fungal and bacterial microbiota of healthy (i.e., without rot symptoms) and rotten (i.e.,